PittsburghV1, France, Analysis, bibRecord, 000690

New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism

Identifieur interne : 000690 ( France/Analysis ); précédent : 000689; suivant : 000691

New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism

Auteurs : Philipp Kapranov [États-Unis] ; Fatih Ozsolak [États-Unis] ; Sang Woo Kim [France] ; Sylvain Foissac [France] ; Doron Lipson [États-Unis] ; Chris Hart [États-Unis] ; Steve Roels [États-Unis] ; Christelle Borel [Suisse] ; Stylianos E. Antonarakis [Suisse] ; A. Paula Monaghan [France] ; Bino John [France] ; Patrice M. Milos [États-Unis]

Source :

Nature [ 0028-0836 ] ; 2010.

RBID : Hal:hal-01214708

English descriptors

mix :
- genome, mouse, polymerase-II, transcription.

Abstract

Small (<200 nucleotide) RNA (sRNA) profiling of human cells using various technologies demonstrates unexpected complexity of sRNAs with hundreds of thousands of sRNA species present. Genetic and in vitro studies show that these RNAs are not merely degradation products of longer transcripts but could indeed have a function. Furthermore, profiling of RNAs, including the sRNAs, can reveal not only novel transcripts, but also make clear predictions about the existence and properties of novel biochemical pathways operating in a cell. For example, sRNA profiling in human cells indicated the existence of an unknown capping mechanism operating on cleaved RNA, a biochemical component of which was later identified. Here we show that human cells contain a novel type of sRNA that has non-genomically encoded 5' poly(U) tails. The presence of these RNAs at the termini of genes, specifically at the very 3' ends of known mRNAs, strongly argues for the presence of a yet uncharacterized endogenous biochemical pathway in cells that can copy RNA. We show that this pathway can operate on multiple genes, with specific enrichment towards transcript-encoding components of the translational machinery. Finally, we show that genes are also flanked by sense, 3' polyadenylated sRNAs that are likely to be capped.

Url:

https://hal.archives-ouvertes.fr/hal-01214708

DOI: 10.1038/nature09190

Affiliations:

France, Suisse, États-Unis

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000408
to stream Hal, to step Curation: 000408
to stream Hal, to step Checkpoint: 000486
to stream Main, to step Merge: 00AB29
to stream Main, to step Curation: 00A383
to stream Main, to step Exploration: 00A383
to stream France, to step Extraction: 000690

Links to Exploration step

Hal:hal-01214708

Le document en format XML

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<front><div type="abstract" xml:lang="en">Small (<200 nucleotide) RNA (sRNA) profiling of human cells using various technologies demonstrates unexpected complexity of sRNAs with hundreds of thousands of sRNA species present. Genetic and in vitro studies show that these RNAs are not merely degradation products of longer transcripts but could indeed have a function. Furthermore, profiling of RNAs, including the sRNAs, can reveal not only novel transcripts, but also make clear predictions about the existence and properties of novel biochemical pathways operating in a cell. For example, sRNA profiling in human cells indicated the existence of an unknown capping mechanism operating on cleaved RNA, a biochemical component of which was later identified. Here we show that human cells contain a novel type of sRNA that has non-genomically encoded 5' poly(U) tails. The presence of these RNAs at the termini of genes, specifically at the very 3' ends of known mRNAs, strongly argues for the presence of a yet uncharacterized endogenous biochemical pathway in cells that can copy RNA. We show that this pathway can operate on multiple genes, with specific enrichment towards transcript-encoding components of the translational machinery. Finally, we show that genes are also flanked by sense, 3' polyadenylated sRNAs that are likely to be capped.</div>
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New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism

New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism

Source :

English descriptors

Abstract

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Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri